The new D&D-seq molecular recording strategy utilizes base-editing enzymes and nanobodies to map DNA-protein interactions at single-cell resolution. This method captures transient regulatory contacts that often escape traditional assays, providing a clearer view of how gene activity is controlled in diverse cell types. By integrating into standard multiomics workflows, D&D-seq enables researchers to monitor how mutations and therapeutic interventions reshape the regulatory landscapes of patient-derived cells.
Read the full article at Genetic Engineering News
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Ali NematiWritten by Ali
