Biotech & Pharma

mRNA Tails Play Key Role in Folding Regulatory Proteins

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New research identifies mRNA 3' UTRs as essential chaperones that assist in the correct folding of thousands of regulatory proteins, including transcription factors like MYC. This discovery matters to researchers because it reveals that the genetic code alone is insufficient for creating functional proteins; RNA-mediated folding in mesh-like condensates is required for biological activity. An implication to watch is how the removal of these RNA tails in laboratory settings may lead to misfolded or inactive proteins.

Read the full article at Genetic Engineering News

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