Biotech & Pharma

SARS-CoV-2 Protein Fuels Lung Inflammation by Hijacking Macrophages

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Researchers have identified the SARS-CoV-2 protein ORF8 as a key driver of lung inflammation in severe COVID-19 cases, demonstrating it reprograms macrophages to enhance viral infection. This finding is significant for the biotech and pharma sectors because it clarifies a mechanism contributing to long-term lung damage beyond initial airway infection, potentially explaining some persistent symptoms. The study suggests that targeting the IL-17RA receptor, already addressed by an approved drug like brodalumab, could offer a therapeutic avenue for mitigating severe COVID-19 pathology.

Read the full article at Genetic Engineering News

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