Researchers at the Icahn School of Medicine have discovered that beneficial gut bacteria utilize epigenetic "bet-hedging" to survive disruptions like antibiotics by shifting functional states without altering their genetic code. For developers engineering AI-driven computational biology models or personalized microbiome therapies, this reveals a critical, non-genetic layer of microbial resilience that must be integrated into predictive models and therapy design algorithms. Understanding these reversible epigenetic switches could lead to targeted interventions that manipulate these states to improve probiotic engraftment and microbiome-based treatments.
Read the full article at Genetic Engineering News
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